Pay attention to APRE stocks. (18%)

2021.09.21 10:36 Full_Raspberry_2452 Pay attention to APRE stocks. (18%)

September 20, 2021 - 4:15 pm
BOSTON, Sept. 20, 2021 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing and commercializing novel cancer therapeutics that reactivate the mutant tumor suppressor protein, p53, today presented data at the European Society of Medical Oncology (ESMO) Congress 2021 from its Phase I/II clinical trial in advanced solid tumors. The trial is evaluating the safety and efficacy of eprenetapopt in combination with pembrolizumab.
As of the July 31, 2021 data cutoff, 33 patients were enrolled on study and 31 had initiated treatment. The Phase I safety lead-in part was a dose de-escalation design and no dose-limiting toxicities were reported in the 6 enrolled patients. A Phase II expansion part was initiated and, as of the data cutoff, has enrolled 3 patients in the gastric/GEJ cancer, 3 in the bladdeurothelial cancer and 19 in the non-small cell lung cancer (NSCLC) cohorts. Patients in the NSCLC Phase II cohort were required to have prior exposure to a PD-1 or PD-L1 inhibitor. Across all patients, 25 (76%) had a mutation in the TP53 gene. The trial continues to enroll and treat patients and exploratory studies involving analyses of patient-derived immune cell populations are ongoing.
In the bladdeurothelial cohort, 1 patient with locally advanced TP53 mutant high-grade transitional cell bladder cancer had achieved complete remission (CR) by RECIST criteria at the first response assessment at 9 weeks. In the NSCLC cohort, 2 patients with TP53 mutant squamous NSCLC had reductions in target lesions of 26.7% and 8.2%, respectively, from baseline by RECIST criteria at the first response assessment at 9 weeks. Adverse events, regardless of causality, were mostly grade 1/2. Grade ≥3 events occurring in more than 1 patient included anemia (3), dyspnea (3), dizziness (2), pain (2) and malnutrition (2). Dizziness (2 patients) was the only grade ≥3 adverse event assessed by an investigator as eprenetapopt-related and occurring in more than 1 patient. One patient experienced a fatal adverse event of disease progression which was assessed by an investigator as not related to study treatment, and one patient experienced adverse events of fatigue, dyspnea and maculo-papular rash leading to discontinuation of eprenetapopt.
“The emerging data for the combination of eprenetapopt and pembrolizumab in these difficult-to-treat patients is very encouraging,” said Dr. Haeseong Park of Washington University in St. Louis. “Particularly promising are tumor reductions in lung cancer patients who previously received I/O therapy, and the complete remission in a bladder cancer patient with prior chemotherapy exposure, which is rare. In addition, the clinical experience to-date suggests the combination is well-tolerated with adverse events readily managed with standard of care measures. The other investigators and I look forward to maturation of the data from this clinical trial as we seek to enroll and treat additional patients with this novel combination.”
About Aprea Therapeutics, Inc.
Aprea Therapeutics, Inc. is a biopharmaceutical company headquartered in Boston, Massachusetts with research facilities in Stockholm, Sweden, focused on developing and commercializing novel cancer therapeutics that reactivate mutant tumor suppressor protein, p53. The Company’s lead product candidate is eprenetapopt (APR-246), a small molecule in clinical development for hematologic malignancies and solid tumors. A pivotal Phase 3 clinical trial of eprenetapopt and azacitidine for frontline treatment of TP53 mutant MDS has been completed and failed to meet the primary statistical endpoint of complete remission. Eprenetapopt is currently on clinical hold in myeloid and lymphoid malignancies. Eprenetapopt has received Orphan Drug and Fast Track designations from the FDA for myelodysplastic syndromes (MDS), Orphan Drug and Fast Track designations from the FDA for acute myeloid leukemia (AML), and Orphan Drug designation from the European Commission for MDS and AML. APR-548, a next generation small molecule reactivator of mutant p53, is being developed for oral administration. For more information, please visit the company website at
The Company may use, and intends to use, its investor relations website at as a means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD.
About p53, eprenetapopt and APR-548
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer, occurring in approximately 50% of all human tumors. These mutations are often associated with resistance to anti-cancer drugs and poor overall survival, representing a major unmet medical need in the treatment of cancer.
Eprenetapopt (APR-246) is a small molecule that has demonstrated reactivation of mutant and inactivated p53 protein – by restoring wild-type p53 conformation and function – thereby inducing programmed cell death in human cancer cells. Pre-clinical anti-tumor activity has been observed with eprenetapopt in a wide variety of solid and hematological cancers, including MDS, AML, and ovarian cancer, among others. Additionally, strong synergy has been seen with both traditional anti-cancer agents, such as chemotherapy, as well as newer mechanism-based anti-cancer drugs and immuno-oncology checkpoint inhibitors.
APR-548 is a next-generation small molecule p53 reactivator. APR-548 has demonstrated high oral bioavailability, enhanced potency relative to eprenetapopt in TP53 mutant cancer cell lines and has demonstrated in vivo tumor growth inhibition following oral dosing of tumor-bearing mice.
Forward-Looking Statement
Certain information contained in this press release includes “forward-looking statements”, within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, related to our study analyses, clinical trials, regulatory submissions, and projected cash position. We may, in some cases use terms such as “future,” “predicts,” “believes,” “potential,” “continue,” “seeks,” “anticipates,” “estimates,” “expects,” “plans,” “intends,” “targeting,” “confidence,” “may,” “could,” “might,” “likely,” “will,” “should” or other words that convey uncertainty of the future events or outcomes to identify these forward-looking statements. Our forward-looking statements are based on current beliefs and expectations of our management team that involve risks, potential changes in circumstances, assumptions, and uncertainties. Any or all of the forward-looking statements may turn out to be wrong or be affected by inaccurate assumptions we might make or by known or unknown risks and uncertainties. These forward-looking statements are subject to risks and uncertainties including risks related to the success and timing of our clinical trials or other studies, risks associated with the coronavirus pandemic and the other risks set forth in our filings with the U.S. Securities and Exchange Commission. For all these reasons, actual results and developments could be materially different from those expressed in or implied by our forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which are made only as of the date of this press release. We undertake no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.
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2021.09.21 10:36 Outrageous_Debt_7286 Rollercoin is an online bitcoin mining simulator in which you can mine real bitcoins for free without paying for electricity - get a 1000 satoshi now!

Rollercoin is a game that you compete with your friends, who will have a bigger farm to mine bitcoin, ethereum or dogecoin. Аll you have to do is register and customize your avatar, then you're ready to start the race.
The best part is that this game does not require depositing money to grow your farm, it is enough to play games, raise enough money and buy your first miner.
Once you have collected the sufficient minimum amount (about 4-6$) you can withdraw your money to your personal wallet. You can take 1000 satoshi which will help for the development of your farm. They are equal to 0.00001 BTC.
It is now possible to progress faster with the new in the game "Event Pass", if you do not want to give real money, there are also free prizes such as, acceleration of production by 1 Ph / s for 1 day and 3 days, as well as 2 Ph / s for 7 days and other gifts.
If you wish, you can develop your mining farm with real money, this is optional!
There are also weekly offers that offer a limited series of miners, as well as discounts for miners up to 60%.
At Rollercoin you will never mine at a loss because you will not pay for electricity! The game is made you always mine to profit!
If you decide to invest the money you earn in miners, you will start earning more.
The cheapest miner costs only 2.6 RLT which is 2.6$.
Notes on using Rollercoin
• All purchases from the site require RLT, which is Rollercoin's own cryptocurrency. There are currently no means of purchasing RLT with real cash (this also applies to other cryptos!). You either must mine them from your "PC" or exchange them via funds from your Rollercoin wallet.
• You may withdraw your crypto from the site once it reaches the required quota, or deposit them to a different currency. You cannot, however, deposit any crypto from outside Rollercoin.
• The cooldown timer after playing the game will pause at any point you opened a tab or another browser to view, and will resume once you click on the site.
• You can only split power from mining crypto once every 12 hours.
• You must win at least one game per day to maintain the current level of your "PC", otherwise it will go back to the lowest level and with it your mining power.
• The more games you win, the more difficult it is, and the longer the cooldown. On the flipside, you get a bigger score which adds to your mining power.
• You can bring down the difficulty of any game by simply not playing them for awhile. Use this to diversify the games you play and earn as much mining power as possible.
• The higher your mining power, the more crypto you can get from each completed block.
• When starting off, switch all mining power to RLT ASAP and win 150 games. This lets you complete most of the Weekly Event quests and have power to gain enough RLT to purchase a miner within a few days (cheapest one as of this writing is 2.6 RLT).
• The last part of the Event Quest get additional XP requires you invite one person to sign up to Rollercoin. That person gets 1000 Satoshi free upon sign-up. 1000 FREE SATOSHI HERE
• Cryptonoid provides the highest score (thus the biggest mining power gain), followed by Dr. Hamster, and Token Blaster. Coin Flip gives the lowest score followed by Coin Click and Coin Match.
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2021.09.21 10:36 prawnbiryani 💗☁🍦🌸🧁🤍🦩

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2021.09.21 10:36 Honestmonster Will there ever be a a Post Raw or Post Smackdown thread?

I know there is a live thread, but most of us don't get to watch either show live because we don't live on the east coast. Tonight was one of the best Raws in a long time. Would love to see what reasonable people here thought of the show. Have no desire to see what people on other subreddits thought. what do you guys think?
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2021.09.21 10:36 funkigreg Wild Dr COVID tweet

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2021.09.21 10:36 Ramo-395 Earth and Mars are two different planets.

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2021.09.21 10:36 ralsen90 Jag ska äta falukorv ikväll..

Ska som sagt äta falukorv ikväll. Först hade jag tänkt att laga korvstroganoff men nu har jag haft några timmar att tänka och har kommit fram till att jag känner mig lite vågad idag, det är dags att kliva utanför boxen. Därför vänder jag mig till er, den svenska eliten. Vad ska jag laga på min falukorv ikväll?
Stort tack för att ni tog er tiden att läsa och ett större tack om ni tar er tiden att faktiskt hjälpa mig!
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2021.09.21 10:36 KlassicLoL Social Media Team is still undefeated

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2021.09.21 10:36 psychmaniac2233 I think I'm turning into a natural lucid dreamer

Ever since my first lucids they increased exponentially, going from one a month, to 2 or 3 a month, to 1 a week and I'm breaking that threshold now, it happens multiple times a week now. And the thing is, I barely even do any techniques, I just keep turning lucid. And if I've had one and wake up, the next dreams that night are pretty much guaranteed lucids. It's pretty cool. Anyone else with this gift? I'm pretty sure I'm gonna be a natural lucid dreamer by the end of the year, I'm hyped yo
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2021.09.21 10:36 Ok_Resident_2744 Can I buy this game code US even I live in Europe? It will work with vpn?

Can I buy this game code US even I live in Europe? It will work with vpn? submitted by Ok_Resident_2744 to xbox [link] [comments]

2021.09.21 10:36 EiPayaso YouTube: Truth Is Resonance | Esoteric prESSENCE | One Love

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2021.09.21 10:36 Antacidax Why does no one remember geothermal? It's sad.

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2021.09.21 10:36 sarannkhg Solutions Manual of College Algebra: Graphs and Models by Bittinger, Beecher, Ellenbogen & Penna | 5th edition

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2021.09.21 10:36 largolloyd Mesprit 0772 1453 1930

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2021.09.21 10:36 DemianShiller Kavian Finance

Kavian Finance is Launching its Second Layer! 🚀
If you lost the chance on the first layer this is when! 💎
1000 Tokens as Initial Supply
4% To Auto lp
1% Burned
Emission Rate: 0.04
Fair Launch 🔥
Tg: u/KavianFinance
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2021.09.21 10:36 BryanLaubscher Honey bou

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2021.09.21 10:36 prawnbiryani 💗☁🍦🌸🧁🤍🦩

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2021.09.21 10:36 trexxeon Can the Aurelle led panels be wall mounted?

I know that the aurelle is made for ceilings, but can they be mounted on the wall as well?
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2021.09.21 10:36 prawnbiryani 💗☁🍦🌸🧁🤍🦩

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2021.09.21 10:36 heinaga1989 Mem coins came first, now it's time for GIF coin

Meme Coins Came First, and now it's Time For GIF coins to take over
Welcome to the First GIF coin on the BSC you are part of the early squad. And I personally Welcome you to $GIF COIN
We are working on the Website at the Moment and will keep you updated on that.
Roadmap is also coming soon. This isn't a pump n dump. We at GIF coin want this to be a long term project. Diamond hands wanted!
If we are successful, and can show that we are not here for a 2 day project. I will implement the USE Case, and fill you on on my Surprise.
I have been in the space now since January, and have been taking notes all throughout my journey. Making connections and networking around to bring you all the best project I can bring you.
So let's do our part, invite all of your friends here on TG to the project. And let's have some fun! I LOVE GIFs I'm sure you have seen me in the groups posting them. Press the search button on the gif and type what ever sentence you are about to type in text, and GIF it up, can we make an the chat GIF only?! I THINK YES! So let's be creative. There are NO rules as to what you post. But keep it mind, if your going to be offensive, you can sure as shit expect backlash 😀
ALSO if and when we want marketing we will source it out. SO PLEASE PLEASE PLEASE feel free to ROAST every Pajeet Marketer that comes in wanting us to promote us 😀
Welcome to GIF coin ladies and gentlemen
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2021.09.21 10:36 Omer013 Jordan 1 Mocha from WTG 198¥

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2021.09.21 10:36 remlutupse Paul Fredrick MenStyle Coupon Code Reddit

Here is the Paul Fredrick MenStyle Coupon Code Reddit
Looking for more coupons ? You can find more coupons on this page. Also you can use the site search to find any coupons you want.
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2021.09.21 10:36 Daniele86 cartolina-aforisma-michail-bakunin-0

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2021.09.21 10:36 bimbonet WHY IS CRYPTOCURRENCY SO IMPORTANT?

Twitter can censor because it’s their 'platform'
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2021.09.21 10:36 epokchad When pepsi is SUS

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